**Core Concept**
The absorption of certain drugs can be influenced by food intake, particularly fatty or high-calorie meals, which can alter the solubility, solubilization, and intestinal permeability of these compounds.

**Why the Correct Answer is Right**
Primaquine is a classic example of an anti-malarial drug whose absorption is significantly enhanced by food intake. The mechanism behind this phenomenon is thought to be related to the presence of fatty acids in food, which can solubilize primaquine and increase its intestinal permeability. This results in improved bioavailability and higher peak plasma concentrations of the drug.

**Why Each Wrong Option is Incorrect**
**Option A:** Chloroquine's absorption is generally unaffected by food intake. Its bioavailability is relatively high and not significantly influenced by the presence of food.
**Option B:** Mefloquine's absorption may be affected by factors such as gastric pH and the presence of food, but it is not as strongly influenced by food as primaquine.
**Option C:** Amodiaquine's absorption is also relatively unaffected by food intake, and its bioavailability is generally considered to be stable across different meal conditions.

**Clinical Pearl / High-Yield Fact**
When prescribing primaquine, it is essential to advise patients to take the medication with a meal to optimize absorption and minimize the risk of gastrointestinal side effects.

**Correct Answer: C. Primaquine**