Absolute contraindication of OCP’s is:
**Core Concept**
Absolute contraindications to Oral Contraceptive Pills (OCPs) are conditions that pose a significant risk to the patient's health if OCPs are used. These contraindications are based on the potential for increased risk of thromboembolic events, hypertension, and other adverse effects.
**Why the Correct Answer is Right**
The correct answer is **Thrombophilic disorders**. This is because patients with thrombophilic disorders, such as protein C deficiency, protein S deficiency, or antithrombin III deficiency, are at an increased risk of developing thromboembolic events, including deep vein thrombosis and pulmonary embolism. The use of OCPs can further increase this risk, making thrombophilic disorders an absolute contraindication to OCP use.
**Why Each Wrong Option is Incorrect**
**Option A:** **Migraines with aura** is a relative contraindication, not an absolute contraindication. While patients with migraines with aura may be at an increased risk of stroke, the risk can be managed with careful selection of OCPs and monitoring.
**Option B:** **Hypertension** is a relative contraindication, not an absolute contraindication. While OCPs can increase blood pressure, the risk can be managed with careful selection of OCPs and monitoring.
**Option C:** **Breast cancer** is a relative contraindication, not an absolute contraindication. While there may be a small increased risk of breast cancer with OCP use, this risk is generally considered to be small and temporary.
**Clinical Pearl / High-Yield Fact**
When considering the use of OCPs in patients with a history of thromboembolic events or thrombophilic disorders, it's essential to carefully weigh the risks and benefits and consider alternative forms of contraception, such as progestin-only pills or intrauterine devices.
**Correct Answer:** C.