About first-order kinetics, the true statement is
Correct Answer: Clearance remains constant
Description: Most of the drugs follow 1st order kinetics in 1st order kinetics-clearance is constant and, elimination is not saturable, and the rate of drug elimination is directly propoional to the concentration. This is usually referred to as first-order elimination Reference: Katzung Pharmacology; 13th edition; Chapter 3; Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action
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