About Burkitt&;s lymphoma, true is-
**Core Concept**
Burkitt's lymphoma is a type of **non-Hodgkin lymphoma** characterized by a specific genetic translocation involving the **c-MYC** gene. This translocation leads to uncontrolled cell proliferation. It is highly aggressive and typically affects the **abdomen** or **jaw**.
**Why the Correct Answer is Right**
The correct answer is related to the clinical presentation or genetic characteristics of Burkitt's lymphoma. The disease is known for its rapid growth and is often associated with **Epstein-Barr virus** infection. The **c-MYC** translocation is a hallmark of this disease, driving the malignant transformation of B cells.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it does not accurately describe the primary characteristic of Burkitt's lymphoma.
**Option B:** Incorrect as it is not specific to Burkitt's lymphoma.
**Option C:** Incorrect because, although related to lymphomas, it is not the defining feature of Burkitt's lymphoma.
**Clinical Pearl / High-Yield Fact**
A key point to remember about Burkitt's lymphoma is its rapid growth rate and potential for **tumor lysis syndrome** upon initiation of chemotherapy, necessitating close monitoring and aggressive supportive care.
**Correct Answer:** D. Characterized by translocation of c-MYC gene.