In Acne with associated endocrinological abnormalities like polycystic ovarian syndrome (PCOS) manifests with obesity, hirsutism, androgenetic alopecia and acne. Oestrogens and antiandrogens(cyproterone acetate, spirono lactone, flutamide) and agents designed to inhibit the endogenous production of androgens by the ovary(oral contraceptives and gonadotropin releasing agonists) or adrenal gland(low dose glucocoicoids ) are used Reference Harrison20th edition pg 1206