A post operative patient developed septicemia and was empirically started on combination chemotherapy by a new resident doctor. However, when the patient did not respond even after 10 days of antibiotics treatment, the review of the charts was done. It was found that the resident doctor had started the combination of antibiotics which was mutually antagonistic in action. Which of the following is the most likely combination that was given?
Correct Answer: Ampicillin and chloramphenicol
Description: Ans. (C) Ampicillin and chloramphenicol (See below)(Ref: KDT 8/e p749)Combination of a bactericidal (ampicillin) and a bacteriostatic drug (chloramphenicol) is usually antagonistic in nature. This is because cidal drugs are usually acting on a fast multiplying organisms whereas static drugs decrease this multiplication.
Category:
Pharmacology
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