A patient with known mutation in the ‘Rb gene’ is ‘disease free’ from Retinoblastoma. The patient is at highest risk of developing which of the following malignancies
Correct Answer: Osteosarcoma
Description: Ans. (b) OsteosarcomaRef: Pathology and Genetics of Tumors of Soft tissue and Bone (Who Classification of Tumors); Oncology and Basic Science' by Damrone (Lippincott/Williams); Robbins'Second site primary malignant tumors refer to non metastatic tumors arising in disease free patients. Tumors associated with retinoblastoma include osteosarcoma, fibrosarcoma, chondrosarcoma, Ewing's sarcoma, Epithelial malignant tumor, lymphoma, leukemia melanoma, brain tumors and pinealoblasstomas. Osteogenic sarcomas are the most frequent second site neoplasms in all the published series'.
Category:
Ophthalmology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now