**Core Concept**
The ABO blood group system in humans is determined by the presence or absence of specific antigens on the surface of red blood cells. Individuals with A-negative (A-) blood group have A antigens but lack the B antigen. To receive blood safely, transfusion compatibility must be ensured to prevent an adverse immune response.
**Why the Correct Answer is Right**
A patient with A-negative blood group can receive blood from other A-negative individuals because they share the same A antigen on their red blood cells. This is due to the principle of isohemagglutination, where antibodies against the A antigen are naturally present in the plasma of individuals with B or AB blood groups. However, in the case of A-negative recipients, their plasma lacks anti-A antibodies, making it possible to transfuse A-negative blood without triggering an adverse reaction.
**Why Each Wrong Option is Incorrect**
* **Option A:** Receiving blood from an A-positive donor would expose the A-negative recipient to A antigens, triggering an immune response and potentially leading to hemolysis.
* **Option B:** Transfusing blood from a B-positive donor would expose the A-negative recipient to B antigens, which are naturally present in their plasma, potentially leading to hemolysis.
* **Option C:** Receiving blood from an AB-positive donor would expose the A-negative recipient to both A and B antigens, triggering an immune response and potentially leading to hemolysis.
**Clinical Pearl / High-Yield Fact**
A-negative blood group individuals can safely receive blood from other A-negative individuals due to the absence of anti-A antibodies in their plasma.
**Correct Answer:** C.
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