A patient was being treated with a drug that interfaces with the activity of enzyme pyruvate ferredoxin oxidoreductase; Which of the following is the most likely organism causing infection in this patient?
Correct Answer: Beef tapeworm
Description: For Taenia saginata(Beef tapeworm): Praziquantel, Niclosamide Niclosamide Niclosamide is a highly effective drug against cestodes infesting man-Taenia saginata, T. solium, Diphyllobothrium latum and Hymenolepis nana, as well as threadworm. The drug appears to act by inhibiting oxidative phosphorylation in mitochondria and interfering with anaerobic generation of ATP by the tapeworm. Nitazoxanide: This salicylamide congener of the anthelmintic niclosamide, recently introduced for the treatment of giardiasis is also active against E. histolytica, T. vaginalis, Cryptosporidium, H. pylori, Ascaris, H. nana and some other protozoa and helminths. It is a prodrug which on absorption is conveed to the active form tizoxanide, an inhibitor of PFOR enzyme that is an essential pathway of electron transpo energy metabolism in anaerobic organisms ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:802,814
Category:
Pharmacology
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