A patient taking ketoconazole and terfenadine both, is prone to –
Correct Answer: Cardiac arrythmia
Description: Ans. is 'a' i.e., Cardiac arrhythmia o Terfenadine causes blockade of delayed rectifier K+ channels in the hea at higher concentration and can cause Torsades De Pointes (Polvmorph ventricular tachcardia) --> Prolonged QT interval. Drugs inhibiting the metabolism of terfenadine by inhibiting CYP3AY enzyme, can precipitate ventricular arrythmia Erythromycin, clarithromycin, itraconazole, ketoconazole.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now