Answer is A (Goodpasture's syndrome) Association of hematuria and hemoptysis suggest a diagnosis of Goodpasture's syndrome. Goodpasture's syndrome and ANCA ANCA is typically negative in Goodpastures syndrome and it is classified as an ANCA negative vasculitis Neveheless ANCA seropositivity may occur in upto 30 percent of patients with Goodpasture's.syndrome. These patients with ANCA have subtle signs of a systemic vasculitis and represent an overlap between goodpastures and either Wegener's granulomatosis (WG) or Microscopic polyangitis(MPA)-Current Diagnosis and Treatment in Pulmonary Medicine