A patient presents with cervical lymphadenopathy. Biopsy demonstrates a nodular lymphoma with follicle formation. This lesion would most likely be associated with which of the following?
Correct Answer: bcl-2 activation
Description: Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas. Must know: An abl-bcr hybrid and t(9, 22) translocation are associated with chronic myeloid leukemia (CML). c-myc activation and t(8, 14) are associated with Burkitt's lymphoma. Ref: Robbins Basic Pathology, 8th Ed, page 20-21;198-199
Category:
Pathology
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