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A patient presenting with history of diarrhoea for several years with recent onset pruritus and raised alkaline phosphatase, normal SGOT/PT and USG shows no gallstones and biliary tract abnormality, the diagnosis is

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Correct Answer:
Sclerosing cholangitis
Description:
Symptoms of PSC Evidence of cholestatic liver disease - Jaundice, Pruritus and fatigue Diagnosis Asymptomatic elevation of GGT is the earliest finding, ALP and bile acids are also increased. Cholangiography - diagnoisis of PSC with evidence of diffuse multifocal strictures found in both intrahepatic and extrahepatic bile ducts Ref: Sabiston 20th edition Pgno :1508-1509
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