A patient on anti-tubercular drug therapy developed tingling sensation on lower limb. Which of the following drug should be used for the treatment?
Correct Answer: Pyridoxine
Description: Patient is developing tingling sensation (peripheral neuropathy) which is a side effect of Isoniazid (INH) a first line antitubercular drug. INH is extensively metabolized in liver; most impoant pathway being N-acetylation by NAT2. The acetylated metabolite is excreted in urine. The rate of INH acetylation shows genetic variation. There are either: Fast acetylators: (30-40% of Indians) t1/2 of INH 1 hr. Slow acetylators: (60-70% of Indians) t1/2 of INH 3 hr. Slow acetylators will not be able to metabolize the drug quickly and there will be accumulation of isoniazid. Isoniazid inhibits pyridoxal phosphokinase enzyme and hence causes peripheral neuritis, paraesthesias, numbness etc. Pyridoxine given prophylactically (10mg/day) prevents this neurotoxicity. On the other hand, fast acetylators are more prone to develop.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now