Propofol has a rapid onset of action. Awakening from a single bolus dose is also rapid due to a very sho initial distribution half-life (2-8 min). Most investigators believe that recovery from propofol is more rapid and is accompanied by less "hangover" than recovery from methohexital, thiopental, ketamine, or etomidate. This makes it a good agent for outpatient anesthesia. Propofol's shoer duration of action after infusion can be explained by its very high clearance, coupled with the slow diffusion of drug from the peripheral to the central compament. Ref: Butterwoh IV J.F., Mackey D.C., Wasnick J.D. (2013). Chapter 9. Intravenous Anesthetics. In J.F. Butterwoh IV, D.C. Mackey, J.D. Wasnick (Eds), Morgan & Mikhail's Clinical Anesthesiology, 5e.