Medical MCQ - A patient having prinzmetal angina is started with ISMN. Patient got symptomatic relief from angina. What is the MOA?

A patient having prinzmetal angina is started with ISMN. Patient got symptomatic relief from angina. What is the MOA?

Endothelium independent coronary vasodilatation

Reduced cardiac contractility

Increased left ventricular end diastolic volume

Decreased diastolic perfusion pressure

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Correct Answer:

Endothelium independent coronary vasodilatation

Description:

ANS. A# Important points on nitrates1. All nitrates have high FPM metabolism except ISMN (Isosorbide mononitrate)2. Skin rashes are maximum with Pentaerythritol tetranitrate3. Nitrates used in acute attack: NTG and ISDN (Isosorbide dinitrite)

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