A fixed drug eruption (FDE) is an adverse cutaneous reaction to an ingested drug, characterized by the formation of a solitary (but at times multiple) erythematous patch or plaque. Most commonly implicated agents in fixed drug eruptions: Tetracyclines (tetracycline, minocycline) Sulfonamides, other sulfa drugs Metronidazole, nystatin, salicylates, NSAIDs, phenylbutazone, phenacetin Barbiturates Oral contraceptives Quinine (including quinine in tonic water), quinidine Phenolphthalein Food coloring (yellow): in food or medications Ref: (2013). Section 23. Adverse Cutaneous Drug Reactions1. In Wolff K, Johnson R, Saavedra A.P. (Eds), Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology, 7e.