Medical MCQ-A paediatrician was called for attending a new born baby in the labour ward. The serum unconjugated bilirubin of this baby was 33 mg/dL. Which of the following drug taken by mother in late 3rd trimester may have lead to this problem?

A paediatrician was called for attending a new born baby in the labour ward. The serum unconjugated bilirubin of this baby was 33 mg/dL. Which of the following drug taken by mother in late 3rd trimester may have lead to this problem?

Cotrimoxazole

Azithromycin

Ampicillin

Chloroquine

Question Category:

Pharmacology

Correct Answer:

Cotrimoxazole

Description:

Bilirubin given in question is very high; Bilirubin binds to Albumin in blood, so when any drug displaces bilirubin from albumin, it can lead to increased free bilirubin. Cotrimoxazole is a combination of trimethoprim and sulfamethoxazole (a sulfonamide). Sulfonamides (acidic drugs) can displace bilirubin from albumin resulting in excessive free bilirubin. This can cross blood brain barrier in newborn babies which can cause Kernicterus; hence avoided in pregnancy.

Previous MCQ

Next MCQ

Get More

Subject Mock Tests

Try practicing mock tests with over 200,000 questions from various medical subjects.

Attempt a mock test now

Mock Exam

Attempt an exam of 100 questions randomly chosen from all subjects.

Coming Soon