A new drug is found to be highly lipid soluble. It is metabolized at a slower rate of 10% per hour. On intravenous injection, it produces general anaesthesia that lasts only for 15 min. This short duration of anaesthesia is due to:
Correct Answer: Redistribution
Description: - Highly lipid soluble drugs get initially distributed to organs with high blood flow (Brain, heart, kidney etc). Later to less vascular tissues (muscle, fat). The plasma concentration falls and the drug is withdrawn from these sites. If the site of action was in one of the highly perfused organs, redistribution results in termination of drug action. Greater the lipid solubility of the drug, faster is its redistribution. This is seen in Thiopentone.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now