- Highly lipid soluble drugs get initially distributed to organs with high blood flow (Brain, heart, kidney etc). Later to less vascular tissues (muscle, fat). The plasma concentration falls and the drug is withdrawn from these sites. If the site of action was in one of the highly perfused organs, redistribution results in termination of drug action. Greater the lipid solubility of the drug, faster is its redistribution. This is seen in Thiopentone.