A neonate presents with jaundice and clay coloured stools. Liver biopsy shows giant cells diagnosis is –
Correct Answer: Neonatal hepatitis with extrahepatic biliary atresia
Description: Jaundice with clay coloured stools suggests cholestasis.
Both neonatal hepatitis and extrahepatic biliary atresia cause cholestasis jaundice.
"Giant cells" are characteristics of both neonatal hepatitis and Extrahepatic Biliary Atresia.
Therefore the answer is Neonatal hepatitis with extrahepatic Biliary Atresia.
Idiopathic neonatal hepatitis
It is also referred to as giant cell hepatitis.
This type of cholestatic jaundice of unknown cause presents with features of cholestasis and a typical liver biopsy appearance.
It is characterized by -
i) Obstructive jaundice (cholestasis) ii) Giant cell transformation in liver Ili) Patent bile ducts
Presenting features are suggestive of intrahepatic cholestasis -
Acholic stools o Emesis o IUGR
Poor feeding o Prematurity o Poor growth
Category:
Pediatrics
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