Medical MCQ-A neonate is being investigated for jaundice. A liver biopsy shows features of a

A neonate is being investigated for jaundice. A liver biopsy shows features of a “Giant Cell/Neonatal hepatitis”. Which one of the following conditions usually results in this case –

Congenital hepatic fibrosis

Hemochromatosis

Alpha–1–antitrypsin deficiency

Glycogen storage disease Type 1

Question Category:

Pediatrics

Correct Answer:

Alpha–1–antitrypsin deficiency

Description:

Other conditions which also presents with similar clinical and histological features (i.e., with giant cells) a) ai antitrypsin deficiency b) Alagille syndrome c) Niemann - Pick type C disease (NPC). d) Viral infections e) Byler disease f) Progressive familial intrahepatic cholestasis (PFIC).

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