Answer- C. Damage to both respiratory apparatus and respiratory centre'Depression of the respiratory center by a variety of drugs, injury, or disease can produce respiratory acidosis.This may occur acutely with general anesthetics, sedatives, and head trauma or chronically with sedatives, alcohol, intracranial tumors, and the syndromes of sleep-disordered breathing including the primary alveolar and obesity-hypoventilation syndromes.'- Harrison I8/e p371