Medicine A middle aged man noticed that he can no longer fit in his shoes and enlarging of jaw and phalanges. These effects are mediated by? A ACTH B TRH C Somatomedin D TGF beta 💡 Explanation A middle aged man noticed that he can no longer fit in his shoes and enlarging of jaw and phalanges. These effects are mediated by? ✓ Correct Answer: C. Somatomedin