Dent's disease :Dent's disease, a familial proximal tubular syndrome, is an X-linked recessive disorder of proximal tubules characterized by :Hypercalciuria and nephrocalcinosis and nephrolithiasis. Low-molecular-weight proteinuria. Metabolic bone disease/Rickets. Progressive renal failure. Marked inale predominance.In addition to above features, other renal proximal tubular defect can cause:(i) Fanconi syndrome (Aminoaciduria, proteinuria, phosphaturia). (i) Glycosuria, uricosuria and kalliuresis. (iii) Impaired urinary acidification.Dent's disease occurs due to mutations that inactivate a voltage-gated chloride transporter, CLC-.5. In some cases, it is associated with mutations in the OCRL-1 gene that is also mutated in the oculocerebral syndrome of Lowe. Coming back to question. Dent's disease is an X-linked renal tubular disorder.X-linked disease cannot be transmitted from male to male i.e., from father to son.