Physiology A major causal factor in some cases of hypogonadism is: A Reduced secretion of gonadotropin-releasing hormone (GnRH) B Hypersecretion of pituitary LH and FSH as the result of increased GnRH C Excess secretion of testicular activin by Sertoli cells D Failure of the hypothalamus to respond to testosterone 💡 Explanation A major causal factor in some cases of hypogonadism is: ✓ Correct Answer: A. Reduced secretion of gonadotropin-releasing hormone (GnRH)