A lung biopsy of a HIV patient showed intra nuclear basophilic inclusion bodies with perinuclearhalo.The patient’s CD4 was les then 100 at the time of diagnosis. What is the probable cause?
Correct Answer: CMV
Description: Cytomegalovirus (CMV) is a double-stranded DNA virus in the herpes virus family that can cause disseminated or localized end-organ disease in HIV-infected patients with advanced immunosuppression. Retinitis is the most common clinical manifestation of CMV end-organ disease in HIV-infected patients. Laboratory tests will be done on a sample of tissue taken from your stomach or intestine. The tests, such as a gastric or intestinal ,lungtissue culture or biopsy, determine if the virus is in the tissue. A CMV serology test is done to look for antibodies to the CMV virus in your blood Ref Harrison20th edition pg 987
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