CMV retinitis is the most common ocular infection in AIDS patient.CMV retinitis Presentation :Presents as a painless progressive loss of vision. Patients may also complain of 'blurred vision', Floaters and scintillations.Opthalmoscopic findings : (Bilateral)Characteristic retinal appearance ofperivascular haemorrhages and retinal exudates - Harrison Cotton wool spots appearing as a result of focal ischaemia of nerve fibre layer are characteristicRisk factors :The majority of cases of CMV retinitis occur in patients with CD4+ count < 50/ 1. Patients with CD4+ count < 100 / 1 should undergo an ophthalmic examination every 3-6 months.Treatment:Therapy for CMV retinitis consists of intravenous ganciclovir Forscarnet (cidofovir is an alternative).