Medical MCQ-A highly specific inhibitor that targets the phosphorylation activity of TFIIH is added to an in vitro transcription reaction. Which one of the following steps is most likely to be affected?

A highly specific inhibitor that targets the phosphorylation activity of TFIIH is added to an in vitro transcription reaction. Which one of the following steps is most likely to be affected?

Binding of RNA polymerase to promoter sequence

Promoter clearance

Recruitment of TFIID

Open promoter complex formation

Question Category:

Biochemistry

Correct Answer:

Promoter clearance

Description:

Most likely to be affected by inhibitor that targets the phosphorylation activity of TFIIH is promoter clearance Transcription factor II H has two activities : Helicase Kinase -Unwinds the DNA -Phosphorylates the TFIIH- Promoter clearance.

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