A genetic disorder renders fructose 1, 6–biphosphatase in liver less sensitive to regulation by fructose 2, 6–biphosphate. All of the following metabolic changes are observed in this disorder except
Correct Answer: Level of fructose 1, 6–biphosphate is higher than normal
Description: Level of fructose 1, 6-biphosphate is higher than normal
Fructose-1, 6-bisphosphatase is inhibited by fructose-2, 6-bisphosphate.
If fructose-1, 6-bisphosphatase becomes less sensitive to inhibition caused by fructose-2, 6-bisphosphate, its activity will increase and there will be increased conversion of fructose-1, 6-bisphosphate into fructose-6-phosphate (reaction catalyzed by fructose-1, 6-bisphosphatase).
Thus, level of fructose-1, 6-bisphosphate will decrease.
Fructose-1, 6-bisphosphatase is a regulating enzyme for gluconeogenesis, and therefore gluconeogenesis will increase.
As the cycle will shift more toward gluconeogenesis, glycolysis will decrease with a resultant decrease in production of ATP and pyruvate.
Category:
Biochemistry
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