Medical MCQ - A factor that is likely to increase the duration of action of a drug D that is partially metabolized by CYP3A4 in the liver is:

A factor that is likely to increase the duration of action of a drug D that is partially metabolized by CYP3A4 in the liver is:

Chronic administration of phenobarbital with the drug

Chronic administration of cimetidine with the drug

Displacement from tissues binding sites by another drug

Chronic administration of rifampicin

Question Category:

Correct Answer:

Chronic administration of cimetidine with the drug

Description:

- Microsomal enzyme inducers- Rifampicin, Phenobarbital- will increase the activity of enzymes, leading to decreased duration of action of a drug. - Microsomal enzyme inhibitor- Cimetidine- will decrease the activity of enzyme resulting in increased duration of action of the drug. - A drug displaced from the binding site gets easily metabolized.

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