Needlestick injury is the most common cause of HIV infection among health care workers. The guidelines for post-exposure prophylaxis of HIV areA) For routine exposuresa combination of two nucleoside reverse transcriptase inhibitors for 4 weeks.B) For high risk or complicated exposuresa combination of two nucleoside reverse transcriptase inhibitors plus a protease inhibitor for 4 weeks. Inspite of the guidelines regimen B is given for all types of exposureThus the treatment is obvious in this doctor.Also Remember Examples of Nucleoside reverse transcriptase inhibitorsZidovudine Lamivudine Stavudine Didanosine Zalcitabine A bacavirProtease inhibitorsSaquinavir Indinavir Ritonavir NelfinavirAmprenavir