Biochemistry A decrease in the level of heme leads to a reduction in globin synthesis in reticulocytes. Which of the following best explains this phenomenon? A RNA polymerase activity is decreased in reticulocytes by low heme B The initiation factor eIF-2 becomes phosphorylated,reducing its level of activity C Heme normally activates peptidyl transferase in reticulocytes D A tRNA degrading enzyme is active in the absence of heme 💡 Explanation A decrease in the level of heme leads to a reduction in globin synthesis in reticulocytes. Which of the following best explains this phenomenon? ✓ Correct Answer: B. The initiation factor eIF-2 becomes phosphorylated,reducing its level of activity