Idiopathic thrombocytopenic purpura -quantitative disorder of platelets caused by antibodies directed against platelet or megakaryocytic antigens -related to antibody-mediated immune destruction of platelets or their precursors. -The peripheral blood smear in ITP exhibits numerous large platelets, and the bone marrow shows a compensatory increase in megakaryocytes. - C/F Petechia Purpura Hemorrhagic bullae Gum bleeding Hematuria Melena *Thrombocytopenia may be observed in the other choices but is usually associated with other systemic signs and symptoms.