A 80-year-old woman is brought by her daughter due to progressive forgetfulness over the past few years. She often forgets the way home and cannot remember the right words. She also has problem in multi-tasking. Lately she has trouble doing activities of daily living and has also developed agnosia, aphasia and anomia but gait of the patient is normal. Which of the following structures would be most likely atrophied in this patient and the gene affected: –