Cachexia, or wasting due to cancer manifests with weakness, weight loss, anorexia, anemia, and infection. The principal cytokine responsible for such changes is tumor necrosis factor-a (TNF-a). -Both platelet-derived growth factor and fibroblast growth factor are involved in wound healing. -Interleukin-2 (IL-2) is an immuno-stimulating cytokine produced by activated T cells. -Vascular endothelial growth factor is impoant in the proliferation of blood vessels in a growing tumor.