A 65-year-old woman with a history of breast cancer and a recent melanoma presents to the emergency room following a tonic-clonic seizure. Blood chemistry values are within normal limits. There is no history of drug or alcohol use. MRI of the brain shows bilateral cerebral edema and a cystic, frontal lobe lesion. Frozen section obtained from a CT-guided biopsy reveals a hemorrhagic nodule of neoplastic cells. Immunohistochemical stains for which of the following antigens would be most helpful in making your diagnosis definitive for melanoma?
A 65-year-old woman with a history of breast cancer and a recent melanoma presents to the emergency room following a tonic-clonic seizure. Blood chemistry values are within normal limits. There is no history of drug or alcohol use. MRI of the brain shows bilateral cerebral edema and a cystic, frontal lobe lesion. Frozen section obtained from a CT-guided biopsy reveals a hemorrhagic nodule of neoplastic cells. Immunohistochemical stains for which of the following antigens would be most helpful in making your diagnosis definitive for melanoma?
💡 Explanation
A 65-year-old woman with a history of breast cancer and a recent melanoma presents to the emergency room following a tonic-clonic seizure. Blood chemistry values are within normal limits. There is no history of drug or alcohol use. MRI of the brain shows bilateral cerebral edema and a cystic, frontal lobe lesion. Frozen section obtained from a CT-guided biopsy reveals a hemorrhagic nodule of neoplastic cells. Immunohistochemical stains for which of the following antigens would be most helpful in making your diagnosis definitive for melanoma?
✓ Correct Answer: B. HMB-45
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