Negative feedback mechanisms ensure a proper level of hormone activity at the target tissue. After a stimulus (plasma glucose) causes a release of the hormone (insulin), conditions or products resulting from the action of the hormone (decrease sugar) tend to suppress its fuher release. In other words, the hormone (or one of its products) has a negative feedback effect to prevent oversecretion of the hormone or overactivity at thetarget tissueThe increase in plasma insulin lowers the plasma glucose concentration which in turn results in decreased insulin secretion