A 60-year-old man has resting tremor, pill-rolling movements, rigidity, and bradykinesia. Which of the following is most likely to be decreased in this man?
Correct Answer: Dopamine neurons in the substantia nigra
Description: The clinical features points toward a diagnosis of Parkinson disease. It is characterized by loss of dopaminergic neurons that project from the substantia nigra to the putamen. Other options: Serotonergic raphe neurons have been implicated in the control of mood and descending pain modulation (analgesia) pathway. GABAergic pathway loss from striatum (caudate nucleus + putamen) results in hyperkinetic disorder, Huntington disease. Loss of nucleus basalis of Meyne in the basal forebrain, a diffuse cholinergic projection to the entire neocoex, the amygdala, and the hippocampus leads to Alzheimer disease.
Category:
Physiology
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