A 6 – year – old boy with lymphoreticular malignancy has come for a cycle of chemotherapy. Which of the following investigatins need to be done for next 4 hours to diagnose tumour lysis syndrome?
Correct Answer: Urea, creatinine, phosphate, Ca2+ and K+
Description: Tumour lysis syndrome (TLS) - -Uric acid, phosphate and potassium are released in large quantities from death of tumour cells. -Hyperuricemia can lead to impairment of renal function, which fuher exacerbates the metabolic abnormalities. -Hypocalcaemia is a consequence of acute hyperphosphatemia with subsequent precipitation of calcium phosphate in soft tissues. 'TLS can occur before therapy in patients with a large tumour burden (e.g., Burkitt lymphoma, Hyperleukocytosis) It is usually seen within 12-48 hr of initiating chemotherapy.
Category:
Pediatrics
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