Hyperophy Response to trophic signals or increased functional demand and is commonly a normal process. The molecular basis of hyperophy reflects the increased expression of growth-promoting genes (proto-oncogenes) such as myc and ras. -Hyperplasia (choice C) of renal tubular cells may occur, but an enlargement of the kidney in this patient is best referred to as hyperophy (i.e., increased organ size and function). Diagnosis: Hyperophy