A 52-year-old recent immigrant from Vietnam complains of abdominal swelling, weight loss, and upper abdominal pain of 3 weeks in duration. His past medical history includes malaria and infection with the liver fluke Clonorchis sinensis. The liver is hard on palpation. An abdominal CT scan shows a hypo-attenuated mass with lobulated margins in the liver. A biopsy discloses well-differentiated neoplastic glands embedded in a dense fibrous stroma. Which of the following is the most likely diagnosis?
A 52-year-old recent immigrant from Vietnam complains of abdominal swelling, weight loss, and upper abdominal pain of 3 weeks in duration. His past medical history includes malaria and infection with the liver fluke Clonorchis sinensis. The liver is hard on palpation. An abdominal CT scan shows a hypo-attenuated mass with lobulated margins in the liver. A biopsy discloses well-differentiated neoplastic glands embedded in a dense fibrous stroma. Which of the following is the most likely diagnosis?
💡 Explanation
A 52-year-old recent immigrant from Vietnam complains of abdominal swelling, weight loss, and upper abdominal pain of 3 weeks in duration. His past medical history includes malaria and infection with the liver fluke Clonorchis sinensis. The liver is hard on palpation. An abdominal CT scan shows a hypo-attenuated mass with lobulated margins in the liver. A biopsy discloses well-differentiated neoplastic glands embedded in a dense fibrous stroma. Which of the following is the most likely diagnosis?
✓ Correct Answer: B. Cholangiocarcinoma
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