When diet changes fail, hypolipidemic drugs can reduce serum cholesterol & triacylglycerol. A family of drugs known as statins have proved highly efficacious in lowering plasma cholesterol and preventing  heart disease. Statins act by inhibiting HMG-CoA  reductase and up-regulating LDL receptor activity. Examples currently in use include atorvastatin, simvastatin, fluvastatin and pravastatin. Ezetimibe reduces blood cholesterol levels by inhibiting the absorption of cholesterol by the intestine by blocking uptake via the Niemann-Pick C-like 1 protein. Other drugs used include fibrates such as clofibrate, gemfibrozil, and nicotinic acid, which act mainly to lower plasma triacylglycerols by decreasing the secretion of triacylglycerol and cholesterol-containing VLDL by the liver.  High plasma cholesterol levels are >5.2 mmol/L. Reference: HARPERS ILLUSTRATED BIOCHEMISTRY30th ed Page no 276