A 50 year old male is taking medication for tuberculosis since the last 2 months comes to the OPD with a complaint of hearing problems. The drug with which of the following mechanisms of action is most likely causing these symptoms?
Correct Answer: Binds to 30S Ribosome subunit and inhibits initiation complex
Description: Streptomycin used in Tuberculosis produce ototoxicity. Aminoglycosides act by inhibiting protein synthesis after binding to the 30s ribosome and inhibiting 1st step - initiation complex formation.Ref: Katzung 13th ed Pg 799
Category:
Pharmacology
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