A 50-year-old chronic alcoholic presented with complaints of acute confusion, delirium, ataxia and mild memory loss. On ophthalmoscopic examination, ophthalmoplegia was noted along with hypotension. Serum electrolyte levels were normal. Lab findings revealed increased RBC transketolase activity along with reduced blood lactate levels. CT scan of the brain did not reveal any finding, so MRI of brain was planned. Which of the following enzymes uses the above deficient vitamin as a coenzyme: –
Correct Answer: Pyruvate dehydrogenase
Description: This is a case of Wernicke's encephalopathy. It occurs due to deficiency of vitamin B1. The clinical diagnosis of WE in alcoholics requires two of the following four signs: dietary deficiencies eye signs cerebellar dysfunction either an altered mental state or mild memory impairment. This MRI shows typical high signal intensities (SIs) in the medial thalamus (A), periaqueductal gray (B), mamillary bodies (C), cerebellar vermis (B, C, D), and paravermian superior cerebellum (D). All the lesions represent high SIs on the DWI (E-H). ENZYMES USING THIAMINE AS COENZYME: - Pyruvate dehydrogenase Transketolase Xanthine dehydrogenase uses vitamin B2 as cofactor. Transaminases and decarboxylases use vitamin B6 as cofactor.
Category:
Unknown
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now