Wiskott Aldrich syndrome Etiopathogenesis: X linked recessive disorder Defect in WASP gene (Chr Xp11) Clinical: Characterized by recurrent infections, eczema like rash & thrombocytopenia Prolonged bleeding from circumcision site Bloody diarrhea Streptococcus pneumoniae & other bacteria having polysaccharide capsules cause otitis media, pneumonia, meningitis & sepsis Investigation findings: Thrombocytopenia with small sized platelets IgM: low IgE & IgA: elevated