A 45 years male HIV-1 positive was staed on a cA regimen of Tenofovir-Emtricitabine-Eirenz. After 9 months, he developed Eirenz resistance which lead to failure of therapy. Which of following drug of the same class can be used in place of Eirenz?
Correct Answer: Etravirine
Description: Etravirine is Non-Nucleoside Reverse Transcriptase Inhibitor (NNI). Etravirine in combination with other anti-retrovirals is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients Resistance to other NNIs does not confer resistance to Etravirine so it can be used in place of Eirenz . Nelfinavir is a protease inhibitor and not NNI Nevirapine, Delavirdine, and Eirenz are NNIs
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