A 42-year-old man is on amitriptyline for depression. Recently he has been feeling more lethargic and unwell. His clinical examination is normal. Serum sodium is 125 mEq/L and osmolality is 260 mOsm/kg, and urine sodium is 40 mEq/L and osmolality is 450 mOsm/kg.For the above patient with hyponatremia, select the most likely diagnosis.
Correct Answer: SIADH
Description: Amitriptyline is one of the psychoactive drugs that cause SIADH. Others include phenothiazines, serotonin reuptake inhibitors, and monoamine oxidase inhibitors (MAOIs). Antineoplastic drugs such as vincristine and cyclophosphamide also cause SIADH, as does the hypoglycemic agent chlorpropamide.
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now