Microbiology A 40 year old farmer presents with chronic cough, fever, anorexia. O/E lymphadenopathy and hepatosplenomegaly present. Chest X-ray shows infiltrates, patchy opacities. Aspiration of lymph node shows intracellular yeasts. Culture grows thick walled spherical spores with tuberculate microconidia. Diagnosis A Cryptococcosis B Sporotrichosis C Histoplasmosis D Coccidioidomycosis 💡 Explanation A 40 year old farmer presents with chronic cough, fever, anorexia. O/E lymphadenopathy and hepatosplenomegaly present. Chest X-ray shows infiltrates, patchy opacities. Aspiration of lymph node shows intracellular yeasts. Culture grows thick walled spherical spores with tuberculate microconidia. Diagnosis ✓ Correct Answer: C. Histoplasmosis