A 35 yr old woman presents with swelling of the small joints of the hands. On examination, swan neck deformity is present. Labs show elevated RA factor levels and high anti-CCP levels. She diagnosed with rheumatoid ahritis and staed on steroids for a sho duration. What is the mechanism by which steroids reduce inflammation?
Correct Answer: Inhibition of phospholipase A2
Description: Steroids reduce inflammation by: Inhibiting phopholipase A2, the precursor of arachdonic acid. Arachidonic acid is the precursor for prostagladins and leukotrienes, which inhibits phospholipase A2. Inhibit the production of interleukin-2 (IL-2) and proliferation A2. Inhibit the release of histamine and serotonin from mast cells and platelets. Ref: Guyton and Hall 13th edition Pgno: 975
Category:
Physiology
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